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If acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin syndrome in a particular patient, PRISTIQ should be stopped promptly, and linezolid or intravenous methylene blue can be administered.
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Patients who have low CrCl or GFR and receive renally excreted maintenance drugs should have either the dose reduced, the dosing interval extended, or both.
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